Why QuantaKinome™?

Next-Generation Kinome Profiling

Deep and direct kinome pathway activity profiling
Endogenous, human kinase activities
Established, targeted mass-spectrometry (LC-MS/MS) technology
Multiplexed, sensitive and quantitative
Based on a library of 170+ kinase activities
Actionable insights in 10+ key signaling pathways
Optimized for cells, organoids, patient-derived xenografts, fine needle aspirate, tissues, biopsies
Proprietary activation loop-based method
Developed by world-leading scientists

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QuantaKinome™ Features and Benefits

Discovery, Development, and Clinical Applications

Drug development

Target Identification

Compound development

Drug mode-of-action studies

Personalized therapy

Drug testing in patient-derived models

Development of rational polytherapies

Biomarker assay development

Patient stratification

Therapy monitoring

Kinase activity-based therapy selection

Resistance mechanisms

Therapeutic Areas

Oncology
Inflammatory diseases
Immunology
Metabolic disorders
...and many more

The Essence of QuantaKinome™

Human Samples

samples:

- in vitro

- ex vivo

- in vivo

Kinase Digestion

- proteolytic cleavage

- endogenous kinases to peptides

Phosphopeptide Enrichment

isolation of phosphorylated peptides

Kinase Activity Determination

direct quantification of phosphorylated kinase activation (T-) loops with targeted LC-MS

Deep Pathway Profiling

QuantaKinome™ detects 2 to 3 times more active kinases than discovery phosphoproteomics. By generating more information, it provides significantly deeper insights, including the important, low-abundant kinases.

Direct Kinase
Activity Profiling

QuantaKinome™ quantifies the phosphorylation of kinase activation loops (T-loops), providing real information about kinase activity.

INACTIVE KINASE

ACTIVE KINASE