Why QuantaKinome™?
Next-Generation Kinome Profiling
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Deep and direct kinome pathway activity profiling
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Endogenous, human kinase activities
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Established, targeted mass-spectrometry (LC-MS/MS) technology
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Multiplexed, sensitive and quantitative
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Based on a library of 170+ kinase activities
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Actionable insights in 10+ key signaling pathways
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Optimized for cells, organoids, patient-derived xenografts, fine needle aspirate, tissues, biopsies
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Proprietary activation loop-based method
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Developed by world-leading scientists
step
into
the
light
QuantaKinome™ Features and Benefits
Discovery, Development, and Clinical Applications
Drug development
Target Identification
Compound development
Drug mode-of-action studies
Personalized therapy
Drug testing in patient-derived models
Development of rational polytherapies
Biomarker assay development
Patient stratification
Therapy monitoring
Kinase activity-based therapy selection
Resistance mechanisms
Therapeutic Areas
Oncology
Inflammatory diseases
Immunology
Metabolic disorders
...and many more
The Essence of QuantaKinome™
Human Samples
samples:
- in vitro
- ex vivo
- in vivo
Kinase Digestion
- proteolytic cleavage
- endogenous kinases to peptides
Phosphopeptide Enrichment
isolation of phosphorylated peptides
Kinase Activity Determination
direct quantification of phosphorylated kinase activation (T-) loops with targeted LC-MS
Deep Pathway Profiling
QuantaKinome™ detects 2 to 3 times more active kinases than discovery phosphoproteomics. By generating more information, it provides significantly deeper insights, including the important, low-abundant kinases.
Direct Kinase
Activity Profiling
QuantaKinome™ quantifies the phosphorylation of kinase activation loops (T-loops), providing real information about kinase activity.
INACTIVE KINASE
ACTIVE KINASE