Why QuantaKinomeâ„¢?
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Deep and direct kinome pathway activity profiling
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Endogenous, human kinase activities
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Established, targeted mass-spectrometry (LC-MS/MS) technology
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Multiplexed, sensitive and quantitative
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Based on a library of 170+ kinase activities
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Actionable insights in 10+ key signaling pathways
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Optimized for cells, organoids, patient-derived xenografts, fine needle aspirate, tissues, biopsies
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Proprietary activation loop-based method
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Developed by world-leading scientists
step
into
the
light
Next-Generation Kinome Profiling
QuantaKinomeâ„¢ Features and Benefits
Discovery, Development, and Clinical Applications
Drug development
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Target Identification
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Compound development
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Drug mode-of-action studies
Personalized therapy
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Drug testing in patient-derived models
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Development of rational polytherapies
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Biomarker assay development
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Patient stratification
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Therapy monitoring
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Kinase activity-based therapy selection
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Resistance mechanisms
Therapeutic Areas
The Essence of QuantaKinomeâ„¢
Human Samples

samples:
- in vitro
- ex vivo
- in vivo
Kinase Digestion

- proteolytic cleavage
- endogenous kinases to peptides
Phosphopeptide Enrichtment

isolation of phosphorylated peptides
Kinase Activity Determination

direct quantification of phosphorylated kinase activation (T-) loops with targeted LC-MS
Deep Pathway Profiling
QuantaKinomeâ„¢ detects 2 to 3 times more active kinases than discovery phosphoproteomics. By generating more information, it provides significantly deeper insights, including the important, low-abundant kinases.

Direct Kinase
Activity Profiling
QuantaKinomeâ„¢ quantifies the phosphorylation of kinase activation loops (T-loops), providing real information about kinase activity.
INACTIVE KINASE

ACTIVE KINASE