Why QuantaKinome™?
-
Deep and direct kinome pathway activity profiling
-
Endogenous, human kinase activities
-
Established, targeted mass-spectrometry (LC-MS/MS) technology
-
Multiplexed, sensitive and quantitative
-
Based on a library of 170+ kinase activities
-
Actionable insights in 10+ key signaling pathways
-
Optimized for cells, organoids, patient-derived xenografts, fine needle aspirate, tissues, biopsies
-
Proprietary activation loop-based method
-
Developed by world-leading scientists
step
into
the
light
Next-Generation Kinome Profiling
QuantaKinome™ Features and Benefits
Discovery, Development, and Clinical Applications
Drug development
-
Target Identification
-
Compound development
-
Drug mode-of-action studies
Personalized therapy
-
Drug testing in patient-derived models
-
Development of rational polytherapies
-
Biomarker assay development
Patient stratification
-
Therapy monitoring
-
Kinase activity-based therapy selection
-
Resistance mechanisms
Therapeutic Areas
The Essence of QuantaKinome™
Human Samples
samples:
- in vitro
- ex vivo
- in vivo
Kinase Digestion
- proteolytic cleavage
- endogenous kinases to peptides
Phosphopeptide Enrichtment
isolation of phosphorylated peptides
Kinase Activity Determination
direct quantification of phosphorylated kinase activation (T-) loops with targeted LC-MS
Deep Pathway Profiling
QuantaKinome™ detects 2 to 3 times more active kinases than discovery phosphoproteomics. By generating more information, it provides significantly deeper insights, including the important, low-abundant kinases.
Direct Kinase
Activity Profiling
QuantaKinome™ quantifies the phosphorylation of kinase activation loops (T-loops), providing real information about kinase activity.
INACTIVE KINASE
ACTIVE KINASE