Why QuantaKinome™?

  • Deep and direct kinome pathway activity profiling

  • Endogenous, human kinase activities

  • Established, targeted mass-spectrometry (LC-MS/MS) technology

  • Multiplexed, sensitive and quantitative

  • Based on a library of 170+ kinase activities

  • Actionable insights in 10+ key signaling pathways

  • Optimized for cells, organoids, patient-derived xenografts, fine needle aspirate,  tissues, biopsies

  • Proprietary activation loop-based method

  • Developed by world-leading scientists

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Next-Generation Kinome Profiling

QuantaKinome™ Features and Benefits

Discovery, Development, and Clinical Applications

Drug development

  • Target Identification

  • Compound development

  • Drug mode-of-action studies

 

Personalized therapy

  • Drug testing in patient-derived models

  • Development of rational polytherapies

  • Biomarker assay development

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Patient stratification

  • Therapy monitoring

  • Kinase activity-based therapy selection

  • Resistance mechanisms

Therapeutic Areas

The Essence of QuantaKinome™

Human Samples

samples:

- in vitro

- ex vivo

- in vivo

Kinase Digestion

- proteolytic cleavage

- endogenous kinases to peptides

Phosphopeptide Enrichtment

isolation of phosphorylated peptides

Kinase Activity Determination

direct quantification of phosphorylated kinase activation (T-) loops with targeted LC-MS

 

Deep Pathway Profiling

QuantaKinome™ detects 2 to 3 times more active kinases than discovery phosphoproteomics. By generating more information, it provides significantly deeper insights, including the important, low-abundant kinases.

Direct Kinase
Activity Profiling

QuantaKinome™ quantifies the phosphorylation of kinase activation loops (T-loops), providing real information about kinase activity.

INACTIVE KINASE

ACTIVE KINASE